ENJOY THE HOLIDAYS!
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Many individuals who have
experienced a brain injury, stroke, or dementia/memory loss have difficulty
regulating their emotions.  Sufferers find they have exaggerated emotions
or have the urge to express an emotion at an inappropriate time. The common
types of emotions include crying and laughing; some may experience both
laughing and crying, while others experience just one of the two.  This
happens because  brain injury, stroke and dementia can damage the pathways
in the brain responsible for emotional regulation.  The medical term for
this exaggerated or out of context laughing and crying due to a neurological
event is called Pseudobulbar Affect (PBA) or emotional liability. 
Dr. Carol
Lippa at DrexelUniversity College of Medicine  is
hosting a clinical trial for individuals with a brain injury, stroke, or
dementia/memory loss that is associated with PBA.  Participants in this
clinical trial will take a medication that is fully (FDA) approved for PBA due
to other causes.  This is a 3 month, open label study so everyone receives
the medication.  It requires only 3 visits to the clinic and all costs are
covered, including the cost of the medication.  Participants will be
reimbursed for their time and travel expenses.  Additional details can be found
here. Nuedexta has been previously studied in MS and ALS populations and a
scientific paper describing the results of previous clinical trials can be
found here. 
To learn more about this clinical trial, please contact Kate Bowen at
215-762-1776.  If you are unfamiliar with a clinical trial, visit our
previous BrainCorner
Blog Post that describes
exactly what a clinical trial is and what you can expect.  
In addition, If you are traveling, make sure to get a flu vaccine before you go. Make sure travel with double your medication just in case there are traveling issues or delays. In addition, make sure you keep up with your exercise regime, and don't be tempted to skip out on them! A little management can go a long way, helping you to still fully enjoy the holidays in a healthy way!
November is Diabetes Awareness Month, and it’s a good time to review your diabetes list of “Things to Do.”  Taking your medications, having diabetes education classes, and checking blood sugars are very important, but not the only things that people with diabetes need to remember.  Whether you have type 1 or type 2 diabetes, you have to do some regular “maintenance” to reduce your chance of having complications develop.
 Having children is an event that many in Americans choose to embark upon and has been built into the "typical" model of the American dream. While there are many factors that contribute to the decision to have a child, early child care costs from infancy to the start of grade school may be a large deterrent. According to Census Bureau, the cost of child care has almost doubled in the last 25 years. This burden falls heavily on working mothers as they are more likely to leave their jobs to take care of children if they make less than their partner. And once children reach grade school, these women find it difficult to get back into, and become a competitive force in the workplace again.
Regardless of income, many feel the strain of childcare. However some of the hardest hit are those right above the income bracket to receive government assistance and those living in poverty. While the average percent of household income spent on childcare is about 7%, It can be much higher for low income families (about 30%!). This can impact the families ability to pay for other things such as housing, utilities and food; which can effect the health and wellness of every family member.
It is also apparent that this is an issue we are seeing more in young girls.  Girls are more likely to both be cyberbullied and cyberbully someone else. And while many student suicide cases are not based solely on cyber bullying, we have been seeing an increase of (girls especially) suicide in which cyberbullying is involved.  In some of the worst cases, students are sexually assaulted only to have it posted on the internet where they are further humiliated and sometimes blamed for what happened.  Examples like this have come to light recently with cases such as the Stubenville, Ohio rape case. ( As we mentioned in our "Rape Culture Around the World?" entry)
Recently, India has been making headlines around the world for what has been called a rape "epidemic". Rapes of the very young, foreign tourists and violent gang rapes have been causing mass protests in a call for women's rights. One of the stories that sparked the most controversy was the gang rape of a medical student who later died of her injuries (Read Here) Despite protests, cities are still seeing a rise in reported rape cases which is leading to the creation of new anti-rape laws. Bad exposure is definitely effecting their economy as well. Since December, tourism has decreased by 25%, mostly with Western female travelers. Many have criticized India, expressing that their patriarchal culture is to blame. But it has also been argued that there is a culture of rape in the U.S.
From 2004-2008, the U.S was the world leader for reported rapes with about 80,000. however, since so many rapes go unreported. The US Department of justice estimates an actual 300,000 per year (making the 80,000 figure more like 1.3 million).
 Many people who are raped or sexually harassed internalize the issue and begin to blame themselves. 73% of rapes in America are committed by non-strangers and 28% happen between intimate partners. Especially in the case of intimate partners, some people may not understand how to escape a dangerous situation and it may not be easy.
There are different types of stress that effect the people in various ways both mentally and physically. Scientists have found that some of the most dangerous types of stress arise when individuals feel that they have little to no control over their daily responsibilities. This feeling of helplessness is most often found in people with lower socio-economic statues, with income being a major determining factor. Not being able to pay bills, put food on the table, no control within the work environment among other things can lead to constant chemical stress reactions from the body.
This type of stress does not only wear a person down mentally, but can also adversely effect ones' health. Those living with chronic stress tend to live shorter lives than those who do not. They are also significantly more likely to develop health conditions such as diabetes, heart disease and high blood pressure. The "American Dream" implies that anyone can overcome hardships through hard work and determination. While the article explains that predisposition does not have complete control over an individuals future, among more affluent people, those who were never poor still have better health outcomes than those who once were. Why is this? Chronic stress can have a major effect on cognitive function and the brains' nervous system development, sometimes creating lasting effects even if chronic stress is no longer a problem.
This issue goes beyond the individual level because the effects of chronic stress are costly. Some of the conditions those who face high stress and prone to are some of the most expensive to treat. And the extent of inequality may be getting worse. The original article suggests that by investing more time and energy into this population (especially children), in the future, we will start to see an economic return. In addition, this could mean improvement in the quality of health for many who need it.
“Clinical” is the word used to describe all
things patient related, while “trial” is the word used when in the process of
proving or trying something.  Together, a
clinical trial is essentially a research study that involves human volunteers
as the participants.  The volunteers try
a treatment, which may include new or updated drugs, devices, procedures, or
action plans.  The side effects, safety,
optimal dosage, and the overall effectiveness of the treatment are determined
as a result of the clinical trial.  Clinical
trials are a vital component of the research process; without them, we would
not have safe, regulated, and effective drugs available for disease treatment.
When deciding whether or not a clinical trial is right
for you, it is important to be both an informed and savvy participant.  There are many places where you can find information about your condition as well as current trials. Organizations like the NIH and Drexel Medicine are great places to find  up to date information about diseases and current initiatives (specific links included at the end of the post). Also do not be afraid to
express your concerns and hesitations to the research study team. Keep in mind
the following questions: What options do I currently have for treatment?  Am I comfortable with the conditions of the trial?  Are both my caregiver
and I willing to fully commit to this process attending scheduled appointments, following directions, and adhering to all procedures?  What are the risks associated with this
study?  Are the risks worth the potential
reward?  Does my doctor and family
support and encourage my participation in this trial?
Researchers take a number of steps to make clinical
trials as safe as possible, both medically and ethically.  Trials are well regulated to make sure
potential side effects are not missed. Throughout the trial, all volunteers
report any adverse events.  This includes
both minor issues, such as a headache or dizziness, or serious problems,
including hospitalizations and death.  If
patterns of serious problems arise, the clinical trial may be stopped to
prevent any further medical issues.  Clinical
trials are also ethically sound, as they must first be reviewed by an Institutional Review Board (IRB). The IRBs’ mission is to protect the safety and welfare of the
volunteers.  The IRB oversees the study procedures,
ensures all staff have been properly trained, and ensures responsible conduct
of the study.  Click here to learn more about
Drexel’s IRB and patient protection.
Clinical trials include a team of people with important,
individual roles.  The “Principal
Investigator”, or PI, is the doctor who supervises the trial at a certain
location.  The PI is responsible for all
aspects of the research.  The “Study
Coordinator” is your main point of contact. 
The coordinator works directly with the PI and schedules appointments,
draws blood for labs, takes vital signs, administers drugs, and collects and
reports data.  The “Sponsor” is the
company that develops the specific drug. 
Typically, a pharmaceutical company develops a drug and picks different
sites to carry out the study.  As a
volunteer you will have limited to no contact with the sponsor.  The “Participants” are the patients that
volunteer to be in the study.  The
participants are a key aspect to the clinical trials team.  All members of the clinical trials team work
together to reach the ultimate goal of a productive and worthwhile clinical
trial experience.
Having a picnic this summer is a great way to bring the family together and incorporate some nutritious items into your diet, but if you’re not careful you can have some uninvited friends at your picnic. Keep your food as cool as possible during transport to prevent bacteria from growing. Full coolers stay colder longer than a cooler that is only partially full, so pack in your favorite foods and fill to the top with ice. Once you’ve set your food out, make sure it doesn’t stay out for more than 2 hours if it’s 90 degrees or warmer out.
 With the dog-days of summer quickly approaching, we want to make sure you’re aware of several ways to help cool down with the sun heating things up.
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| Dr. Lippa | 

